{"id":2893,"date":"2026-10-01T14:27:01","date_gmt":"2026-10-01T14:27:01","guid":{"rendered":"https:\/\/jxl-069.com\/?p=2893"},"modified":"2026-10-01T14:27:01","modified_gmt":"2026-10-01T14:27:01","slug":"hair-follicle-stem-cells-lactate-research","status":"publish","type":"post","link":"https:\/\/jxl-069.com\/es\/hair-follicle-stem-cells-lactate-research\/","title":{"rendered":"C\u00e9lulas madre del fol\u00edculo y lactato: la ciencia explicada"},"content":{"rendered":"<p class=\"translation-block\"><strong>Solo para investigaci\u00f3n.<\/strong> Este art\u00edculo explica investigaci\u00f3n publicada en laboratorio y en ratones. No describe ning\u00fan tratamiento para personas. JXL-069 es un compuesto experimental de investigaci\u00f3n que no est\u00e1 aprobado y no tiene datos de seguridad en humanos.<\/p>\n<h2>Resumen<\/h2>\n<p>En 2017, un equipo de UCLA demostr\u00f3 en ratones que las c\u00e9lulas madre del fol\u00edculo piloso necesitan producir lactato para despertar e iniciar un nuevo ciclo del pelo. Desactivar la enzima que produce lactato manten\u00eda dormidas a las c\u00e9lulas madre; hacer que las c\u00e9lulas produjeran m\u00e1s lactato las despertaba antes. Este hallazgo es la base cient\u00edfica de la investigaci\u00f3n sobre inhibidores del transportador mitocondrial de piruvato (MPC) como JXL-069 y PP405.<\/p>\n<h2>D\u00f3nde se encuentran las c\u00e9lulas madre del fol\u00edculo piloso<\/h2>\n<p>Cada fol\u00edculo piloso contiene una reserva de c\u00e9lulas madre en una regi\u00f3n llamada protuberancia (bulge). En 1990, Cotsarelis, Sun y Lavker encontraron en la protuberancia de fol\u00edculos de rat\u00f3n c\u00e9lulas de ciclo lento que reten\u00edan el marcaje y propusieron que eran las c\u00e9lulas madre del fol\u00edculo (Cotsarelis et al., 1990). Estas c\u00e9lulas aportan las nuevas c\u00e9lulas necesarias cada vez que el fol\u00edculo vuelve a formar el tallo del pelo.<\/p>\n<h2>El ciclo del pelo en breve<\/h2>\n<p>Los fol\u00edculos pilosos pasan por tres fases principales: an\u00e1geno (crecimiento), cat\u00e1geno (regresi\u00f3n) y tel\u00f3geno (reposo). Las etapas est\u00e1n bien definidas en ratones, donde se usan criterios est\u00e1ndar para clasificarlas (M\u00fcller-R\u00f6ver et al., 2001). El momento clave para este tema es el paso de tel\u00f3geno a an\u00e1geno, que requiere que se activen las c\u00e9lulas madre de la protuberancia.<\/p>\n<h2>El estudio del lactato de 2017<\/h2>\n<p>Flores y sus colegas, en los laboratorios de Heather Christofk y William Lowry, investigaron qu\u00e9 cambio metab\u00f3lico acompa\u00f1a a la activaci\u00f3n de las c\u00e9lulas madre. Su estudio en ratones describi\u00f3 varios hallazgos relacionados (Flores et al., 2017):<\/p>\n<ul>\n<li>Al eliminar el gen de la lactato deshidrogenasa A (Ldha) en las c\u00e9lulas madre del fol\u00edculo piloso, las c\u00e9lulas no se activaron y la mayor\u00eda de los fol\u00edculos permaneci\u00f3 en tel\u00f3geno.<\/li>\n<li>Al eliminar el gen del transportador mitocondrial de piruvato (Mpc1) en esas mismas c\u00e9lulas, aument\u00f3 la producci\u00f3n de lactato y el paso de tel\u00f3geno a an\u00e1geno se adelant\u00f3.<\/li>\n<li>Aplicar sobre la piel UK5099, un inhibidor qu\u00edmico del MPC, tambi\u00e9n aceler\u00f3 el ciclo del pelo en ratones.<\/li>\n<li>Un segundo compuesto, RCGD423, activ\u00f3 la se\u00f1alizaci\u00f3n JAK-STAT3, aument\u00f3 los niveles de Myc y la expresi\u00f3n de Ldha, y tambi\u00e9n aceler\u00f3 el ciclo del pelo al aplicarse por v\u00eda t\u00f3pica.<\/li>\n<\/ul>\n<h2>Por qu\u00e9 importa el lactato<\/h2>\n<p>Las c\u00e9lulas transforman la glucosa en piruvato. El piruvato puede entrar en las mitocondrias a trav\u00e9s del MPC o convertirse en lactato mediante la lactato deshidrogenasa. El estudio de 2017 sugiere que, en las c\u00e9lulas madre del fol\u00edculo de rat\u00f3n, el equilibrio entre estas dos v\u00edas funciona como un interruptor: m\u00e1s producci\u00f3n de lactato se asocia a la activaci\u00f3n. Bloquear el MPC desv\u00eda el piruvato hacia el lactato, y por eso los inhibidores del MPC se convirtieron en objeto de investigaci\u00f3n.<\/p>\n<h2>Del hallazgo del lactato a JXL-069 y PP405<\/h2>\n<p class=\"translation-block\">Los mismos grupos de UCLA, junto con el qu\u00edmico Michael Jung, desarrollaron despu\u00e9s una serie de nuevos inhibidores del MPC basados en UK5099. JXL069 fue uno de los m\u00e1s potentes en sus ensayos celulares (Liu et al., 2021). Pelage Pharmaceuticals, fundada por estos investigadores, est\u00e1 probando en ensayos cl\u00ednicos un inhibidor t\u00f3pico del MPC llamado PP405. Consulta <a href=\"https:\/\/jxl-069.com\/es\/what-is-jxl-069-pp405-a-researchers-primer\/\">\u00bfQu\u00e9 es JXL-069?<\/a> y <a href=\"https:\/\/jxl-069.com\/es\/pp405-explained-pelage-clinical-trials\/\">PP405 explicado<\/a>.<\/p>\n<h2>L\u00edmites de la evidencia<\/h2>\n<ul>\n<li>Los hallazgos sobre c\u00e9lulas madre y lactato proceden de ratones. Los ciclos del pelo de rat\u00f3n y de humano difieren en duraci\u00f3n y regulaci\u00f3n.<\/li>\n<li>La eliminaci\u00f3n gen\u00e9tica en ratones no equivale a aplicar un compuesto.<\/li>\n<li>JXL-069 no tiene ning\u00fan tipo de dato en humanos.<\/li>\n<\/ul>\n<p class=\"translation-block\">Para trabajo in vitro y en modelos animales sobre esta v\u00eda: <a href=\"https:\/\/jxl-069.com\/es\/product\/jxl-069-raw-powder\/\">JXL-069 en polvo<\/a> y la <a href=\"https:\/\/jxl-069.com\/es\/product\/jxl-069-pp405-research-serum\/\">soluci\u00f3n JXL-069 (PP405) al 0,05% p\/v de 30 mL<\/a>, solo para investigaci\u00f3n de laboratorio.<\/p>\n<h2>Referencias<\/h2>\n<ol>\n<li class=\"translation-block\">Flores A, Schell J, Krall AS, et al. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017;19(9):1017-1026. <a href=\"https:\/\/doi.org\/10.1038\/ncb3575\" rel=\"nofollow noopener\" target=\"_blank\">doi:10.1038\/ncb3575<\/a><\/li>\n<li class=\"translation-block\">Cotsarelis G, Sun TT, Lavker RM. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell. 1990;61(7):1329-1337. <a href=\"https:\/\/doi.org\/10.1016\/0092-8674(90)90696-c\" rel=\"nofollow noopener\" target=\"_blank\">doi:10.1016\/0092-8674(90)90696-c<\/a><\/li>\n<li class=\"translation-block\">M\u00fcller-R\u00f6ver S, Handjiski B, van der Veen C, et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol. 2001;117(1):3-15. <a href=\"https:\/\/doi.org\/10.1046\/j.0022-202x.2001.01377.x\" rel=\"nofollow noopener\" target=\"_blank\">doi:10.1046\/j.0022-202x.2001.01377.x<\/a><\/li>\n<li class=\"translation-block\">Liu X, Flores AA, Situ L, et al. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss. J Med Chem. 2021;64(4):2046-2063. <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.0c01570\" rel=\"nofollow noopener\" target=\"_blank\">doi:10.1021\/acs.jmedchem.0c01570<\/a><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>Research use only. This article explains published laboratory and mouse research. It does not describe a treatment for people. JXL-069 is an experimental research compound that is not approved and has no human safety data. The short version In 2017, a UCLA team showed in mice that hair follicle stem cells depend on producing lactate [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2893","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hair Follicle Stem Cells &amp; 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